Cs rin ru ck29/8/2023 Being closely related to the AR, the glucocorticoid receptor (GR) has been suggested to play a role in enzalutamide and docetaxel resistance. Although the androgen receptor (AR) has been linked to therapy failure, the underlying escape mechanisms have not been fully clarified. Purpose: The major obstacle in the management of advanced prostate cancer is the occurrence of resistance to endocrine therapy.
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